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A peptide-rich moisturiser with signal peptides, amino acids, growth-factor extracts and soybean extract. Genuinely well-formulated, but the cult status outpaces the evidence. Works well; costs much more than less-famous peptide creams.
What this is good for
✓ Great forAgingfirmnessDamaged Barrier
Ingredient stack
Each ingredient is listed in descending concentration. Above the 1% line the order is regulated — below it, brands can list in any order.
Ingredients above the dashed gold line are dosed above 1% (the regulatory threshold) — these are what the formulation is really built on.
position-estimated %1% regulatory line
What's actually doing the work
Matrixyl 3000
Palmitoyl Tripeptide-1 & Palmitoyl Tetrapeptide-7
Peptide
One of the most clinically studied peptide complexes. Works via two matrikine peptides: Palmitoyl Tripeptide-1 stimulates new collagen I, III and HA synthesis; Palmitoyl Tetrapeptide-7 reduces inflammatory cytokines that break down the dermal matrix. Together they reduce wrinkle depth and improve firmness in 4–12 weeks.
Argireline
Acetyl Hexapeptide-3 / Acetyl Hexapeptide-8
Peptide
Relaxes facial muscle micro-contractions that cause dynamic wrinkles around the eyes and forehead. Often called "topical Botox" — works by interfering with the neurotransmitter release cycle at the neuromuscular junction, gently softening expression lines over 4–8 weeks of consistent use. Most effective at 5–10% concentration.
Routine placement
Morning or evening
Looking for a dupe?
The closest active-matched alternative is the Naturium Multi-Peptide Advanced Moisturizer (66% active overlap). We found 1 option that share this product’s hero actives.
Dupe guide
See all moisturiser dupes for this product
Ranked by ingredient overlap, with an honest note on what’s different in each.
Similar on the shelf
Put this in context
Skin Stacker is independent and receives no payment from any brand. Ingredient analysis is based on publicly disclosed INCI lists and the peer-reviewed literature. Formulations change — always re-check the label on your specific batch before using.