Side-by-side comparison

Drunk Elephant Protini Polypeptide Cream vs Naturium Multi-Peptide Advanced Moisturizer

Both moisturisers contain Matrixyl 3000, but each adds something the other doesn't. Here's where they overlap and where they split.

1Shared hero active
Drunk Elephant
Protini Polypeptide Cream
MoisturiserLuxuryMorning or evening
AgingfirmnessDamaged Barrier

A peptide-rich moisturiser with signal peptides, amino acids, growth-factor extracts and soybean extract. Genuinely well-formulated, but the cult status outpaces the evidence. Works well; costs much more than less-famous peptide creams.

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Naturium
Multi-Peptide Advanced Moisturizer
MoisturiserBudgetMorning or evening
Fine LinesDehydrationDamaged Barrier

A peptide-rich daily moisturiser with Matrixyl, copper peptides and ceramides for firmness and barrier support. An affordable way to fold peptides into a moisturiser step; gentle, fragrance-light and layerable.

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The verdict

Which should you choose?

Both contain Matrixyl 3000. Drunk Elephant Protini Polypeptide Cream adds Argireline. Naturium Multi-Peptide Advanced Moisturizer adds Copper Peptides. Pick the one whose extra matches what you're treating. Drunk Elephant Protini Polypeptide Cream is the better fit for signs of aging and firmness; Naturium Multi-Peptide Advanced Moisturizer for fine lines and dehydration. On price, Naturium Multi-Peptide Advanced Moisturizer is the less expensive option (Budget versus Luxury).

The overlap

What they share

This hero active appears in both formulas:

Matrixyl 3000
The formulation

Ingredient stacks, side by side

Drunk Elephant Protini Polypeptide Cream — top of the list

  • Water~50–80%
  • Glycerin~5–25%
  • Coconut Alkanes~3–10%
  • Dicaprylyl Car…~2–6%
  • Caprylic/Capri…~1.5–4%

Naturium Multi-Peptide Advanced Moisturizer — top of the list

  • Aqua~50–80%
  • Glycerin~5–25%
  • Caprylic/Capric…~3–10%
  • Cetearyl Alcohol~2–6%
  • Palmitoyl Tripe…~1.5–4%

● marks ingredients that appear near the top of both lists. Percentages are positional estimates from INCI order, not disclosed doses.

At a glance

The specs

Drunk Elephant Protini Polypeptide CreamNaturium Multi-Peptide Advanced Moisturizer
CategoryMoisturiserMoisturiser
Price tierLuxuryBudget
Best forAging, firmness, Damaged BarrierFine Lines, Dehydration, Damaged Barrier
Usage notesMorning or eveningMorning or evening
Shared hero activesMatrixyl 3000
Questions

Common questions

Is the Drunk Elephant Protini Polypeptide Cream or the Naturium Multi-Peptide Advanced Moisturizer better?
It depends on what you're treating. Both contain Matrixyl 3000; Drunk Elephant Protini Polypeptide Cream adds Argireline; Naturium Multi-Peptide Advanced Moisturizer adds Copper Peptides.
What's the difference between the Drunk Elephant Protini Polypeptide Cream and the Naturium Multi-Peptide Advanced Moisturizer?
Drunk Elephant Protini Polypeptide Cream's hero actives are Matrixyl 3000 and Argireline. Naturium Multi-Peptide Advanced Moisturizer's are Matrixyl 3000, Copper Peptides and Ceramides. They also sit in different price tiers (Luxury versus Budget).
Are the Drunk Elephant Protini Polypeptide Cream and Naturium Multi-Peptide Advanced Moisturizer dupes for each other?
Partly. They share Matrixyl 3000, but Drunk Elephant Protini Polypeptide Cream's Argireline and Naturium Multi-Peptide Advanced Moisturizer's Copper Peptides aren't in the other, so they aren't full substitutes.
Can I use the Drunk Elephant Protini Polypeptide Cream and Naturium Multi-Peptide Advanced Moisturizer together?
They both fill the moisturiser slot in a routine, so you'd normally pick one. If you like both, use one in the morning and the other at night, and patch-test when introducing anything new.
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