🩺 Skin Conditions

Acne Vulgaris

Acne / Pimples / Spots / Breakouts

What It Is

A chronic inflammatory skin condition involving the hair follicle and sebaceous gland (pilosebaceous unit). Acne develops through four key mechanisms: excess sebum production (driven by androgens), follicular hyperkeratinisation (abnormal cell buildup inside the pore), colonisation by Cutibacterium acnes bacteria, and the resulting inflammatory response. Manifests as comedones (open/closed), papules, pustules, nodules, and cysts. Grades range from mild (comedonal) to severe (nodulocystic). One of the most common skin conditions globally, affecting ~85% of people aged 12–24.

Key Context

Treatment is tailored to grade and type. Mild: BHA (salicylic acid), niacinamide, benzoyl peroxide. Moderate: retinoids (adapalene, tretinoin), azelaic acid, topical antibiotics (short-term). Severe: oral isotretinoin (Accutane), oral antibiotics. Diet (low glycaemic, omega-3s, probiotics) increasingly supported by evidence.

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