Name: Differin Adapalene Gel 0.1%
Brand: Differin

The only third-generation retinoid available OTC in the US — prescription-strength acne treatment for comedonal and inflammatory breakouts. Expect 4–6 weeks of purging before visible clearing. Do not combine with benzoyl peroxide in the same layer unless formulated together (adapalene is stable, most other retinoids aren't).

The verdict

What this is good for

✓ Great forAcneRough Texture

⚠ Skip ifPregnancyBreastfeedingSensitive skinDamaged barrierVery dry skin

The formulation

Ingredient stack

Each ingredient is listed in descending concentration. Above the 1% line the order is regulated — below it, brands can list in any order.

Ingredients above the dashed gold line are dosed above 1% (the regulatory threshold) — these are what the formulation is really built on.

0.1%Adapalene

~5–25%Carbomer 940

~3–10%Edetate Disodium

~2–6%Methylparaben

~1.5–4%Poloxamer 182

~1–2%Propylene Glycol

~1–2%Purified Water

≤ 1% each1 more ingredient below 1%

position-estimated %★ brand-disclosed %1% regulatory line

Hero actives

What's actually doing the work

Adapalene

Differin / Third-Generation Retinoid

Retinoid

Third-generation synthetic retinoid — selective for RARβ and RARγ subtypes and photostable. Originally prescription-only Differin, now OTC at 0.1%. FDA-approved for acne with emerging evidence for anti-aging. Most tolerable prescription-class retinoid — better suited than tretinoin for sensitive or easily irritated skin.

Full glossary entry →

When to use

Routine placement

Evening only

Next steps

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Skin Stacker is independent and receives no payment from any brand. Ingredient analysis is based on publicly disclosed INCI lists and the peer-reviewed literature. Formulations change — always re-check the label on your specific batch before using.