Acetyl Octapeptide-3
An extended version of Argireline with two additional amino acids, designed to interact with SNAP-25 protein more efficiently. Inhibits SNARE complex formation to relax muscles driving expression wrinkles. Clinical evidence suggests greater potency than Argireline at comparable concentrations.
At these concentrations this ingredient should appear above the 1% line on the INCI list. If you see it listed after preservatives or fragrance allergens, the dose is likely too low to work as marketed.
Topical serum 4–8%, AM and/or PM. Most potent applied to expression-prone areas before lighter serums set.
Build a routine using Skin Stacker's free AI-powered tool — decode any product, check ingredient compatibility, and get a personalised AM/PM schedule.
Open Skin Stacker →