Glycation

What It Is

A non-enzymatic chemical reaction in which sugar molecules (glucose, fructose) attach to proteins or lipids and form Advanced Glycation End Products (AGEs). In skin, glycation primarily targets collagen and elastin fibres — causing them to become stiff, yellow, and cross-linked, leading to loss of firmness and a sallow, dull complexion. The rate of glycation is directly correlated with blood sugar levels. High glycaemic diets, diabetes, and UV exposure accelerate AGE formation. One of the most underappreciated mechanisms of skin aging.

Key Context

To minimise glycation: reduce dietary sugar and refined carbohydrates, maintain stable blood glucose (low glycaemic index diet), use topical antioxidants (aminoguanidine, carnosine, EGCG), and apply daily SPF which reduces UV-driven AGE formation.

Learn More

• Anti-Aging Routine
• Science Deep Dives